資料來源：
Baseball Almanac
| Name | Games | Starts | Wins | Losses | ERA | K | BB |
| Cy Young | 906 | 815 | 511 | 316 | 2.63 | 2,803 | 1,217 |
| Walter Johnson | 802 | 666 | 417 | 279 | 2.17 | 3,509 | 1,363 |
| Grover Alexander (bio) | 696 | 600 | 373 | 208 | 2.56 | 2,198 | 951 |
| Christy Mathewson | 635 | 551 | 373 | 188 | 2.13 | 2,502 | 844 |
| Warren Spahn | 750 | 665 | 363 | 245 | 3.09 | 2,583 | 1,434 |
| Kid Nichols | 620 | 561 | 361 | 208 | 2.95 | 1,868 | 1,268 |
| Pud Galvin | 697 | 682 | 360 | 308 | 2.87 | 1,799 | 744 |
| Tim Keefe | 599 | 593 | 342 | 225 | 2.62 | 2,543 | 1,234 |
| Steve Carlton | 741 | 709 | 329 | 244 | 3.22 | 4,136 | 1,833 |
| John Clarkson | 531 | 518 | 328 | 178 | 2.81 | 1,978 | 1,191 |
| Eddie Plank | 623 | 529 | 326 | 194 | 2.35 | 2,246 | 1,072 |
| Nolan Ryan | 807 | 773 | 324 | 292 | 3.19 | 5,714 | 2,795 |
| Don Sutton | 774 | 756 | 324 | 256 | 3.26 | 3,574 | 1,343 |
| Phil Niekro | 864 | 716 | 318 | 274 | 3.35 | 3,342 | 1,809 |
| Gaylord Perry | 777 | 690 | 314 | 265 | 3.11 | 3,534 | 1,379 |
| Tom Seaver | 656 | 647 | 311 | 205 | 2.86 | 3,640 | 1,390 |
| Old Hoss Radbourn | 528 | 503 | 309 | 195 | 2.67 | 1,830 | 875 |
| Mickey Welch | 564 | 549 | 307 | 210 | 2.71 | 1,850 | 1,297 |
| Lefty Grove | 616 | 457 | 300 | 141 | 3.06 | 2,266 | 1,187 |
| Early Wynn | 691 | 612 | 300 | 244 | 3.54 | 2,334 | 1,775 |
| Robin Roberts | 676 | 609 | 286 | 245 | 3.41 | 2,357 | 902 |
| Fergie Jenkins | 664 | 594 | 284 | 226 | 3.34 | 3,192 | 997 |
| Red Ruffing | 624 | 536 | 273 | 225 | 3.8 | 1,987 | 1,541 |
| Burleigh Grimes | 616 | 497 | 270 | 212 | 3.53 | 1,512 | 1,295 |
| Jim Palmer | 558 | 521 | 268 | 152 | 2.86 | 2,212 | 1,311 |
| Bob Feller | 570 | 484 | 266 | 162 | 3.25 | 2,581 | 1,764 |
| Eppa Rixey | 692 | 553 | 266 | 251 | 3.15 | 1,350 | 1,082 |
| Ted Lyons | 594 | 484 | 260 | 230 | 3.67 | 1,073 | 1,121 |
| Red Faber | 669 | 483 | 254 | 213 | 3.15 | 1,471 | 1,213 |
| Carl Hubbell | 535 | 431 | 253 | 154 | 2.98 | 1,677 | 725 |
| Bob Gibson | 528 | 482 | 251 | 174 | 2.91 | 3,117 | 1,336 |
| Vic Willis | 513 | 471 | 249 | 205 | 2.63 | 1,651 | 1,212 |
| Joe McGinnity | 465 | 381 | 246 | 142 | 2.66 | 1,068 | 812 |
| Amos Rusie | 462 | 427 | 245 | 174 | 3.07 | 1,934 | 1,704 |
| Juan Marichal | 471 | 457 | 243 | 142 | 2.89 | 2,303 | 709 |
| Herb Pennock | 617 | 420 | 240 | 162 | 3.6 | 1,227 | 916 |
| Mordecai Brown | 481 | 332 | 239 | 130 | 2.06 | 1,375 | 673 |
| Waite Hoyt | 674 | 423 | 237 | 182 | 3.59 | 1,206 | 1,003 |
| Whitey Ford | 498 | 438 | 236 | 106 | 2.75 | 1,956 | 1,086 |
| Jim Bunning | 591 | 519 | 224 | 184 | 3.27 | 2,855 | 1,000 |
| Catfish Hunter | 500 | 476 | 224 | 166 | 3.26 | 2,012 | 954 |
| Stan Covelski | 450 | 385 | 215 | 142 | 2.89 | 981 | 802 |
| Chief Bender | 459 | 334 | 212 | 127 | 2.46 | 1,711 | 712 |
| Jesse Haines | 555 | 388 | 210 | 158 | 3.64 | 981 | 871 |
| Don Drysdale | 518 | 465 | 209 | 166 | 2.95 | 2,486 | 855 |
| Bob Lemon | 460 | 350 | 207 | 128 | 3.23 | 1,277 | 1,251 |
| Hal Newhouser | 488 | 374 | 207 | 150 | 3.06 | 1,796 | 1,249 |
| Rube Marquard | 536 | 404 | 201 | 177 | 3.08 | 1,593 | 858 |
| Jack Chesbro | 392 | 332 | 198 | 132 | 2.68 | 1,265 | 690 |
| Dennis Eckersley | 1,071 | 361 | 197 | 171 | 3.5 | 2,401 | 738 |
| Dazzy Vance | 442 | 347 | 197 | 140 | 3.24 | 2,045 | 840 |
| Ed Walsh | 430 | 315 | 195 | 126 | 1.82 | 1,736 | 617 |
| Rube Waddell | 407 | 340 | 193 | 143 | 2.16 | 2,316 | 803 |
| Lefty Gomez | 368 | 320 | 189 | 102 | 3.34 | 1,468 | 1,095 |
| Sandy Koufax | 397 | 314 | 165 | 87 | 2.76 | 2,396 | 817 |
| Addie Joss | 286 | 260 | 160 | 97 | 1.89 | 920 | 364 |
| Dizzy Dean | 317 | 230 | 150 | 83 | 3.02 | 1,163 | 453 |
| Hoyt Wilhelm | 1,070 | 52 | 143 | 122 | 2.52 | 1,610 | 778 |
| Rollie Fingers | 944 | 37 | 114 | 118 | 2.9 | 1,299 | 492 |
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